The child was treated with amphotericin B based on preliminary results, and had a gradual recovery with no neurological sequelae. Bacterial culture of the skin biopsy, CSF and blood culture specimens was negative. The India ink stain and Cryptococcus neoformans latex agglutination test on the CSF were both positive. 5 When the brain is infected, symptoms include headache, fever, neck pain, nausea and vomiting. 4 9 Cough, difficulty breathing, chest pain and fever are seen when the lungs are infected. The cerebrospinal fluid (CSF) had normal protein, glucose and chloride levels yeasts were observed on Gram stain from the CSF and skin scraping. Cryptococcosis is a potentially fatal fungal infection of mainly the lungs, presenting as a pneumonia, and brain, where it appears as a meningitis. A septic screen, including skin scraping, was performed the child was treated with penicillin and ceftriaxone for suspected meningococcal meningitis. On examination the child was confused, uncooperative, and had neck stiffness and raised skin lesions. 1 Altmetric Metrics Abstract Cryptococcuria is a rare manifestation of localized cryptococcal disease. The first case of cryptococcus meningitis and skin lesions in a 4-year-old confirmed HIV negative boy who presented with fever, meningism and skin lesions is reported. Disseminated cryptococcosis is an uncommon occurrence in immunocompetent populations and occurs mainly in immunocompromised patients. Not dimorphic no mold form Does not form hyphae or pseudohyphae Thick polysaccharide capsule.
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